mRNA transport

Across TCGA cell cohorts, RNA activity of the mRNA transport pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIK3, SBDSP1, and DHTKD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIK3 grouped by mRNA transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SIK3 →	+0.330	+0.081	.007	.004	3	5
LUNG_NSCLC_LUAD	SBDSP1 →	+0.163	+0.054	<.001	<.001	3	4
BLOOD_Leukemia	DHTKD1 →	+0.187	+0.090	.006	.001	3	4
BLOOD_Leukemia	ERC1 →	+0.264	+0.104	.003	.001	3	4
PANCREAS	PCDHGA3 →	+0.376	+0.088	<.001	.004	3	4
LUNG_NSCLC_LUSC	ZSCAN29 →	-0.203	-0.103	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIK3 by mRNA transport activity — PANCREAS

Explore this box plot interactively →