Barbed-end actin filament capping

Across TCGA patient cohorts, RNA activity of the Barbed-end actin filament capping pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS3, MYOM1, and HROB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Barbed-end actin filament capping activity versus RBMS3 in LUAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RBMS3 →	+0.546	+0.389	<.001	.004	3	7
LUAD	MYOM1 →	+0.783	+0.311	<.001	.006	3	6
LUAD	HROB →	-0.761	-0.374	<.001	<.001	3	6
LUAD	POC1A →	-0.402	-0.295	.005	<.001	3	6
UCEC	TK1 →	-1.302	-0.293	<.001	<.001	3	6
GBM	FAT4 →	+0.894	+0.219	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051016 vs RBMS3 — LUAD

Explore this scatter interactively →