Barbed-end actin filament capping

Across TCGA cell cohorts, RNA activity of the Barbed-end actin filament capping pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAG, DSTN, and HNMT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SAG grouped by Barbed-end actin filament capping-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SAG →	+0.418	+0.702	.002	.004	3	3
UPPER_AERODIGESTIVE_TRACT	DSTN →	-0.752	-0.328	.003	<.001	3	3
SKIN	HNMT →	-2.172	-0.893	<.001	.001	3	3
SKIN	ZNF154 →	-0.120	-0.640	.002	.004	3	3
BLOOD_Lymphoma	VBP1 →	-1.212	-0.437	.005	.003	3	3
CNS	QARS1 →	-0.333	-0.859	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SAG by Barbed-end actin filament capping activity — BLOOD_Leukemia

Explore this box plot interactively →