Barbed-end actin filament capping

Across TCGA cell cohorts, RNA activity of the Barbed-end actin filament capping pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A3, GSTK1, and ICAM3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Barbed-end actin filament capping activity versus SLC16A3 in BLOOD_Leukemia (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC16A3 →	+2.596	+0.261	<.001	<.001	3	5
OESOPHAGUS	GSTK1 →	+0.985	+0.378	.003	.001	3	5
BLOOD_Leukemia	ICAM3 →	+1.921	+0.161	<.001	.009	3	5
URINARY_TRACT	BCKDK →	+0.995	+0.462	.007	.002	3	4
URINARY_TRACT	DEXI →	+0.696	+0.425	.001	.001	3	4
OVARY	KIFBP →	+0.692	+0.291	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051016 vs SLC16A3 — BLOOD_Leukemia

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