Regulation of lipoprotein lipase activity

pathway activity — cross-omics
GO:0051004Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of lipoprotein lipase activity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIF1A-AS3, WSB1, and ENO2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMHIF1A-AS3 →+0.733+0.179<.001<.00136
LSCCWSB1 →+0.438+0.109<.001<.00135
LSCCENO2 →+1.032+0.135.001.00335
PDACC4orf3 →+0.321+0.084.004.00135
PDACDNAJB6P2 →+0.629+0.089<.001.00435
OVPFKFB4 →+0.709+0.124.004.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration