Positive regulation of lipid catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of lipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IRS2_S1100, PDGFRL, and IRS1_T453, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid catabolic process activity versus IRS2_S1100 in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IRS2_S1100 →	+0.798	+0.034	<.001	<.001	3	6
OV	PDGFRL →	+0.678	+0.038	.001	.001	3	5
LUAD	IRS1_T453 →	+0.710	+0.056	.001	<.001	3	5
GBM	FAM114A1 →	+0.471	+0.048	.001	.004	3	5
LSCC	COL11A1 →	+0.952	+0.061	<.001	<.001	3	5
BRCA	IRS2 →	+0.432	+0.029	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050996 vs IRS2_S1100 — BRCA

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