Positive regulation of lipid catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of lipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, SCN1B, and C3orf18, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid catabolic process activity versus IRS2 in UCEC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS2 →	+1.239	+0.986	<.001	<.001	3	9
BRCA	SCN1B →	+0.512	+0.687	.003	<.001	3	5
BRCA	C3orf18 →	+0.832	+0.690	<.001	.001	3	5
HNSC	NPHP1 →	+0.647	+0.753	<.001	.001	3	4
PDAC	IRS1 →	+0.422	+0.716	.008	.002	2	5
BRCA	CPQ →	+0.662	+0.631	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050996 vs IRS2 — UCEC

Explore this scatter interactively →