Positive regulation of lipid catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLBA1, NUDT6, and TXNL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLBA1 grouped by Positive regulation of lipid catabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CLBA1 →	-1.228	-1.414	.009	.003	3	4
CNS	NUDT6 →	-0.476	-0.913	.001	.002	3	4
CNS	TXNL1 →	-0.366	-0.699	.002	.004	3	4
LIVER	CCDC24 →	-1.246	-0.462	<.001	.002	3	4
OESOPHAGUS	ACSL4 →	-1.089	-0.834	<.001	.001	3	3
BREAST	RBL1 →	+0.811	+0.592	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLBA1 by Positive regulation of lipid catabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →