Positive regulation of lipid catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPT1A, BMT2, and PELO, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid catabolic process activity versus CPT1A in OESOPHAGUS (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CPT1A →	+2.282	+1.593	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	BMT2 →	-0.578	-1.636	.004	<.001	3	5
LARGE_INTESTINE	PELO →	-0.706	-1.065	.007	.003	3	5
OVARY	TMBIM6 →	+0.754	+1.472	.005	<.001	3	5
URINARY_TRACT	JPT2 →	-1.192	-1.644	.001	.001	3	4
STOMACH	WRAP73 →	-0.548	-0.937	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050996 vs CPT1A — OESOPHAGUS

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