Negative regulation of lipid catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASA1, DNAJC17, and PPIL4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipid catabolic process activity versus RASA1 in SOFT_TISSUE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RASA1 →	+1.163	+0.207	.006	.006	3	4
BREAST	DNAJC17 →	+0.929	+0.692	<.001	.001	3	3
LUNG_NSCLC_LUAD	PPIL4 →	+0.633	+0.694	.007	.007	3	3
SOFT_TISSUE	LIX1L →	-0.918	-0.212	<.001	.004	3	3
BLOOD_Lymphoma	RBFA →	-1.017	-1.074	.001	.002	3	3
BLOOD_Lymphoma	RAB2A →	+0.795	+1.275	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050995 vs RASA1 — SOFT_TISSUE

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