Detection of mechanical stimulus

Across TCGA patient cohorts, RNA activity of the Detection of mechanical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF208, MYH1, and LAMA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of mechanical stimulus activity versus ZNF208 in OV (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF208 →	+1.139	+0.469	<.001	.005	3	4
BRCA	MYH1 →	+0.221	+0.202	.002	.002	3	3
BRCA	LAMA4 →	+0.695	+0.197	<.001	<.001	3	3
BRCA	SGIP1 →	+0.589	+0.178	.006	.005	3	3
BRCA	PLPP4 →	+0.773	+0.167	<.001	<.001	3	3
BRCA	AKR1B15 →	+1.593	+0.166	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050982 vs ZNF208 — OV

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