Detection of mechanical stimulus

Across TCGA patient cohorts, RNA activity of the Detection of mechanical stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP23_S598, MYLK_S911, and SUN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of mechanical stimulus activity versus ARHGAP23_S598 in BRCA (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP23_S598 →	+0.781	+0.244	<.001	<.001	3	4
OV	MYLK_S911 →	+2.824	+0.368	<.001	<.001	3	3
BRCA	SUN1 →	+0.443	+0.224	<.001	<.001	3	3
OV	BDP1_S2451 →	-1.272	-0.964	<.001	<.001	3	3
PDAC	YTHDF1_S350 →	-0.688	-0.324	<.001	.001	3	3
GBM	CAPN15_S296 →	+0.353	+0.767	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050982 vs ARHGAP23_S598 — BRCA

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