Detection of mechanical stimulus involved in sensory perception

Across TCGA patient cohorts, RNA activity of the Detection of mechanical stimulus involved in sensory perception pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IGFBP7, EIF2S2, and COL5A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of mechanical stimulus involved in sensory perception activity versus IGFBP7 in HNSC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGFBP7 →	+0.567	+0.045	<.001	<.001	3	6
OV	EIF2S2 →	-0.163	-0.026	.004	<.001	3	5
HNSC	COL5A1 →	+0.693	+0.048	<.001	.001	3	5
GBM	TBC1D2B_T277 →	+0.531	+0.041	<.001	<.001	3	5
LSCC	TIMM44 →	-0.255	-0.038	<.001	<.001	3	5
CCRCC	ITGA1 →	+0.334	+0.041	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050974 vs IGFBP7 — HNSC

Explore this scatter interactively →