Detection of mechanical stimulus involved in sensory perception

Across TCGA patient cohorts, RNA activity of the Detection of mechanical stimulus involved in sensory perception pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRFN5, PAQR8, and FCN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of mechanical stimulus involved in sensory perception activity versus LRFN5 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LRFN5 →	+0.706	+0.496	.004	<.001	3	5
GBM	PAQR8 →	+0.609	+0.464	.009	.009	3	5
OV	FCN1 →	+1.150	+0.426	<.001	<.001	3	4
PDAC	SASH3 →	+0.343	+0.285	.007	.001	3	3
PDAC	JAML →	+0.690	+0.256	.001	.005	2	4
PDAC	TMEM71 →	+0.489	+0.294	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050974 vs LRFN5 — GBM

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