Detection of mechanical stimulus involved in sensory perception of pain

Across TCGA patient cohorts, RNA activity of the Detection of mechanical stimulus involved in sensory perception of pain pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D2B_T277, TIMM44, and S100A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of mechanical stimulus involved in sensory perception of pain activity versus TBC1D2B_T277 in LSCC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TBC1D2B_T277 →	+0.373	+0.042	<.001	<.001	3	6
LSCC	TIMM44 →	-0.222	-0.036	.001	.004	3	5
UCEC	S100A1 →	+1.574	+0.077	<.001	<.001	3	5
LSCC	AKAP12_S660 →	+0.489	+0.048	<.001	<.001	3	5
CCRCC	SHE_S69 →	+0.529	+0.056	.003	.001	3	5
OV	RBBP8NL_S262 →	-0.888	-0.093	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050966 vs TBC1D2B_T277 — LSCC

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