Detection of mechanical stimulus involved in sensory perception of pain

Across TCGA patient cohorts, RNA activity of the Detection of mechanical stimulus involved in sensory perception of pain pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K1, ZPR1, and COA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of mechanical stimulus involved in sensory perception of pain activity versus MAP4K1 in PDAC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MAP4K1 →	+0.392	+0.263	.001	.006	3	3
OV	ZPR1 →	-0.282	-0.189	.005	.009	3	3
CCRCC	COA4 →	-0.247	-0.159	<.001	.008	3	3
UCEC	SPIRE2 →	-0.440	-0.544	.006	.009	3	3
UCEC	REXO5 →	-0.465	-0.709	<.001	<.001	3	3
GBM	PPP1R16B →	+1.175	+0.571	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050966 vs MAP4K1 — PDAC

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