Thermoception

Across TCGA patient cohorts, RNA activity of the Thermoception pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADRA2A, CHTF18, and WDR47, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thermoception activity versus ADRA2A in DLBC (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ADRA2A →	+2.812	+0.141	<.001	<.001	3	28
ESCA	CHTF18 →	-0.658	-0.104	<.001	<.001	3	17
KICH	WDR47 →	+1.034	+0.110	<.001	<.001	3	17
MESO	PIF1 →	-0.887	-0.115	<.001	<.001	3	16
THYM	TEDC2 →	-0.862	-0.100	.001	<.001	2	17
ESCA	SCAT2 →	-0.730	-0.160	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050955 vs ADRA2A — DLBC

Explore this scatter interactively →