Thermoception

Across TCGA patient cohorts, RNA activity of the Thermoception pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MPDU1, CAPG, and LRRC1_T480, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thermoception activity versus MPDU1 in UCEC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MPDU1 →	+0.418	+0.056	.006	.004	3	5
UCEC	CAPG →	-0.523	-0.092	<.001	<.001	3	4
COAD	LRRC1_T480 →	+0.403	+0.042	.002	<.001	3	4
BRCA	REXO4 →	-0.440	-0.077	<.001	<.001	3	4
BRCA	RIF1 →	-0.484	-0.077	<.001	<.001	3	4
BRCA	SLC4A1AP →	-0.270	-0.057	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050955 vs MPDU1 — UCEC

Explore this scatter interactively →