Thermoception

Across TCGA cell cohorts, RNA activity of the Thermoception pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN13, OGG1, and CCDC103, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSPAN13 grouped by Thermoception-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TSPAN13 →	+1.552	+1.432	.009	<.001	3	4
STOMACH	OGG1 →	-0.658	-1.620	.009	.001	3	3
SKIN	CCDC103 →	-0.611	-0.592	<.001	.009	3	3
SKIN	PLXNB2 →	+1.242	+0.764	.009	.006	3	3
BLOOD_Leukemia	MEX3B →	-1.623	-0.769	.005	.009	3	3
OESOPHAGUS	ZNF239 →	+1.667	+0.878	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSPAN13 by Thermoception activity — STOMACH

Explore this box plot interactively →