Thermoception

Across TCGA cell cohorts, RNA activity of the Thermoception pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL4A2, H1-2, and SAP130, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COL4A2 grouped by Thermoception-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	COL4A2 →	-0.125	-1.152	.009	<.001	3	4
BLOOD_Myeloma	H1-2 →	+0.169	+1.817	.001	<.001	3	3
SKIN	SAP130 →	-0.153	-0.943	.003	.003	2	4
LUNG_NSCLC_LUSC	RNF170 →	+0.261	+0.124	.002	.002	3	3
LUNG_NSCLC_LUSC	SMYD5 →	-0.256	-0.105	<.001	.005	3	3
LUNG_SCLC	CCNE2 →	+0.192	+1.104	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COL4A2 by Thermoception activity — SKIN

Explore this box plot interactively →