Sensory perception of mechanical stimulus

Across TCGA patient cohorts, RNA activity of the Sensory perception of mechanical stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX39A, PLEKHA6, and REPS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of mechanical stimulus activity versus DDX39A in GBM (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DDX39A →	-0.305	-0.026	<.001	.001	3	6
GBM	PLEKHA6 →	+0.714	+0.037	<.001	<.001	3	6
GBM	REPS2 →	+0.424	+0.026	<.001	<.001	3	5
BRCA	SURF6_S138 →	-0.433	-0.016	.006	<.001	3	5
GBM	KRR1 →	-0.325	-0.027	<.001	<.001	3	5
GBM	TRIM2 →	+0.441	+0.025	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050954 vs DDX39A — GBM

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