Sensory perception of temperature stimulus

Across TCGA cell cohorts, RNA activity of the Sensory perception of temperature stimulus pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP2, LATS2, and FBXO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP2 grouped by Sensory perception of temperature stimulus-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	USP2 →	+0.815	+1.097	.002	.001	3	4
PANCREAS	LATS2 →	-0.912	-0.978	.001	.006	3	4
LUNG_SCLC	FBXO2 →	-3.181	-0.300	.002	.004	3	3
OVARY	ESR1 →	-1.281	-0.534	.003	.004	3	3
STOMACH	DUSP11 →	+0.506	+0.592	<.001	.006	3	3
KIDNEY	ENPP5 →	+0.738	+1.015	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP2 by Sensory perception of temperature stimulus activity — KIDNEY

Explore this box plot interactively →