Regulation of pigment cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of pigment cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSE1L, LUM, and F13A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pigment cell differentiation activity versus CSE1L in COAD (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CSE1L →	-0.398	-0.051	<.001	<.001	2	10
OV	LUM →	+0.849	+0.060	.001	<.001	3	9
BRCA	F13A1 →	+0.536	+0.054	<.001	<.001	3	9
UCEC	GEM_S23 →	+0.905	+0.126	.002	<.001	3	9
UCEC	GIMAP7 →	+0.442	+0.105	<.001	<.001	3	9
HNSC	KANK2_S540 →	+0.612	+0.080	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050932 vs CSE1L — COAD

Explore this scatter interactively →