Regulation of pigment cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of pigment cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MVK, KLF2, and NR4A1AS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pigment cell differentiation activity versus MVK in CCRCC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MVK →	-0.430	-0.392	.005	.009	3	3
CCRCC	KLF2 →	+0.666	+0.506	.002	.004	3	3
CCRCC	NR4A1AS →	+0.621	+0.468	.001	.001	3	3
CCRCC	MIR4653 →	-0.549	-0.420	.003	.005	3	3
LSCC	NCAPD2 →	-0.562	-0.479	.003	.004	3	3
BRCA	FOXM1 →	-1.010	-0.362	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050932 vs MVK — CCRCC

Explore this scatter interactively →