Regulation of pigment cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of pigment cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARSA, MIEF2, and PPP2R5B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARSA grouped by Regulation of pigment cell differentiation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ARSA →	-1.494	-1.662	.002	.001	3	4
LUNG_NSCLC_LUSC	MIEF2 →	-2.287	-2.132	.006	<.001	3	3
OESOPHAGUS	PPP2R5B →	-1.567	-1.743	.002	.009	2	4
SKIN	TMEM132A →	+1.786	+0.293	.001	<.001	3	3
LUNG_NSCLC_LUSC	C1QTNF2 →	-0.780	-1.761	.002	.001	3	3
LUNG_NSCLC_LUSC	PTPN21 →	-1.762	-2.364	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARSA by Regulation of pigment cell differentiation activity — OESOPHAGUS

Explore this box plot interactively →