Pigment cell differentiation

Across TCGA patient cohorts, RNA activity of the Pigment cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, FILIP1L, and FLNA, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment cell differentiation activity versus TLN1 in UCEC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TLN1 →	+0.411	+0.051	<.001	<.001	3	9
UCEC	FILIP1L →	+0.724	+0.053	<.001	<.001	3	9
UCEC	FLNA →	+0.652	+0.056	<.001	<.001	3	9
UCEC	CAMK1 →	+0.381	+0.081	<.001	<.001	3	9
OV	DCN →	+1.019	+0.050	<.001	<.001	3	9
GBM	F13A1 →	+0.866	+0.059	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050931 vs TLN1 — UCEC

Explore this scatter interactively →