Pigment cell differentiation

Across TCGA patient cohorts, RNA activity of the Pigment cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP5, RAN, and TNFSF8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment cell differentiation activity versus GIMAP5 in UCEC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GIMAP5 →	+0.737	+0.949	<.001	<.001	3	5
LSCC	RAN →	-0.366	-0.213	<.001	<.001	3	5
HNSC	TNFSF8 →	+0.509	+0.454	.002	<.001	3	5
HNSC	ANGPTL6 →	+0.277	+0.364	.006	.007	3	5
HNSC	SNED1 →	+0.659	+0.428	<.001	.001	3	5
HNSC	IKZF1 →	+0.592	+0.363	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050931 vs GIMAP5 — UCEC

Explore this scatter interactively →