Pigment cell differentiation

Across TCGA patient cohorts, RNA activity of the Pigment cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP30, ANK2_S1461, and ARHGAP45, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment cell differentiation activity versus ARHGAP30 in HNSC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP30 →	+0.528	+0.556	<.001	<.001	3	4
HNSC	ANK2_S1461 →	+0.917	+0.622	<.001	<.001	3	4
HNSC	ARHGAP45 →	+0.383	+0.461	<.001	<.001	3	4
GBM	PRKCB_T642 →	+0.627	+0.582	<.001	.004	3	4
BRCA	SPHK2_S414 →	+2.586	+1.441	<.001	<.001	3	3
LSCC	KDM3A →	-0.398	-0.214	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050931 vs ARHGAP30 — HNSC

Explore this scatter interactively →