Pigment cell differentiation

Across TCGA cell cohorts, RNA activity of the Pigment cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTAGE15, NECAP2, and EDN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTAGE15 grouped by Pigment cell differentiation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CTAGE15 →	-0.731	-1.756	.001	<.001	3	5
BLOOD_Lymphoma	NECAP2 →	-0.646	-1.981	.006	.003	2	6
LUNG_NSCLC_LUSC	EDN1 →	-2.861	-1.339	<.001	.006	3	4
LUNG_NSCLC_LUSC	SIRT4 →	-0.609	-1.570	<.001	<.001	3	4
LARGE_INTESTINE	CYP2E1 →	+0.812	+0.739	.001	.002	3	4
LUNG_NSCLC_LUAD	SUCLG1 →	+0.439	+0.775	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTAGE15 by Pigment cell differentiation activity — LIVER

Explore this box plot interactively →