Induction of positive chemotaxis

Across TCGA cell cohorts, RNA activity of the Induction of positive chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NTF3, CXCL12, and VEGFD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NTF3 grouped by Induction of positive chemotaxis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NTF3 →	-0.188	-0.905	.001	<.001	3	6
BREAST	CXCL12 →	-0.222	-0.933	<.001	<.001	3	6
OVARY	VEGFD →	-0.330	-0.997	<.001	<.001	3	5
CNS	OR51E2 →	-0.126	-0.595	.002	.005	3	5
LUNG_SCLC	AZU1 →	-0.184	-1.075	.004	.001	3	5
SOFT_TISSUE	ZNF230 →	-0.185	-1.420	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NTF3 by Induction of positive chemotaxis activity — CNS

Explore this box plot interactively →