Induction of positive chemotaxis

Across TCGA cell cohorts, RNA activity of the Induction of positive chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKN2, SIK2, and SPATA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKN2 grouped by Induction of positive chemotaxis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PKN2 →	+0.921	+1.234	.002	.002	3	4
BREAST	SIK2 →	+0.487	+0.628	.005	.009	3	4
LUNG_NSCLC_LUAD	SPATA1 →	+0.382	+0.692	.005	.007	3	4
BLOOD_Leukemia	DUSP19 →	+0.703	+1.083	.003	<.001	3	4
BLOOD_Leukemia	C6orf89 →	+0.780	+1.126	.007	.008	3	4
CNS	SLC15A2 →	+0.581	+0.856	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKN2 by Induction of positive chemotaxis activity — LARGE_INTESTINE

Explore this box plot interactively →