Negative regulation of chemotaxis

Across TCGA patient cohorts, RNA activity of the Negative regulation of chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCF1B, FCGR2B, and CEACAM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemotaxis activity versus NCF1B in LUAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCF1B →	+0.397	+0.160	.001	.004	3	5
LSCC	FCGR2B →	+0.591	+0.141	<.001	.004	3	5
UCEC	CEACAM4 →	+0.577	+0.239	.003	.009	3	4
LSCC	CDX1 →	+0.510	+0.168	<.001	<.001	3	4
LSCC	GPR84 →	+0.573	+0.166	<.001	.001	3	4
BRCA	MGAT1 →	+0.324	+0.252	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050922 vs NCF1B — LUAD

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