Negative regulation of chemotaxis

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX60, IFI27, and SP100, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX60 grouped by Negative regulation of chemotaxis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DDX60 →	+1.496	+1.207	.007	.001	3	5
LUNG_NSCLC_LUAD	IFI27 →	+3.227	+0.952	.002	.001	3	5
OVARY	SP100 →	+1.725	+0.828	.002	.008	3	5
LUNG_SCLC	CRADD →	-0.859	-1.302	<.001	.003	3	5
PANCREAS	MIEF2 →	+0.962	+1.432	.002	<.001	3	4
PANCREAS	SERTAD1 →	+1.162	+1.151	.008	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX60 by Negative regulation of chemotaxis activity — PANCREAS

Explore this box plot interactively →