Negative regulation of chemotaxis

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT8, POC1B, and PPP1R7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemotaxis activity versus NUDT8 in BLOOD_Myeloma (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NUDT8 →	+2.478	+0.419	.004	<.001	3	6
OESOPHAGUS	POC1B →	+0.744	+0.170	<.001	.003	3	5
STOMACH	PPP1R7 →	+0.669	+0.330	.004	.004	3	5
LUNG_NSCLC_LUAD	GPR1 →	-1.536	-0.332	<.001	<.001	3	5
OVARY	SLC38A9 →	-0.782	-0.225	.003	.002	3	5
BLOOD_Myeloma	WNT2B →	-0.166	-0.418	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050922 vs NUDT8 — BLOOD_Myeloma

Explore this scatter interactively →