Regulation of chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYBB, DPYD, and AIF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chemotaxis activity versus CYBB in OV (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYBB →	+0.752	+0.109	.006	.005	3	5
OV	DPYD →	+0.910	+0.172	.001	.001	3	5
OV	AIF1 →	+0.939	+0.151	<.001	<.001	3	5
OV	PTPRC →	+1.116	+0.192	.008	.001	3	5
OV	BIN2 →	+1.018	+0.206	<.001	<.001	3	4
BRCA	MS4A7 →	+1.286	+0.298	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050920 vs CYBB — OV

Explore this scatter interactively →