Regulation of chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYNLRB1, CTSK, and HSPA1L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DYNLRB1 grouped by Regulation of chemotaxis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DYNLRB1 →	+0.427	+0.539	.001	.002	3	3
OESOPHAGUS	CTSK →	+0.763	+0.924	.009	.007	3	3
OESOPHAGUS	HSPA1L →	+0.548	+0.941	<.001	.005	3	3
CNS	ARMC12 →	+0.254	+0.674	.007	.006	3	3
CNS	TBC1D3L →	+1.639	+0.906	<.001	<.001	3	3
BONE	PNPLA2 →	+0.912	+1.627	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DYNLRB1 by Regulation of chemotaxis activity — SKIN

Explore this box plot interactively →