Negative chemotaxis

Across TCGA patient cohorts, RNA activity of the Negative chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC23A, THBS3, and VCAN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative chemotaxis activity versus SEC23A in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEC23A →	+0.300	+0.035	.001	.001	3	8
OV	THBS3 →	+0.724	+0.063	<.001	<.001	3	8
OV	VCAN →	+1.084	+0.047	<.001	<.001	3	8
LSCC	FMNL3 →	+0.367	+0.055	<.001	<.001	3	8
OV	MMP2 →	+0.729	+0.045	<.001	<.001	3	8
LSCC	ARHGEF17 →	+0.288	+0.056	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050919 vs SEC23A — BRCA

Explore this scatter interactively →