Negative chemotaxis

Across TCGA patient cohorts, RNA activity of the Negative chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERMN, DACT3, and CDKL5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative chemotaxis activity versus ERMN in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ERMN →	+1.548	+0.612	<.001	<.001	3	4
BRCA	DACT3 →	+0.743	+0.936	<.001	<.001	3	4
GBM	CDKL5 →	+0.536	+0.605	.001	.001	3	4
BRCA	IRAG1 →	+0.886	+0.771	<.001	<.001	3	4
LSCC	PRICKLE2 →	+0.501	+0.434	<.001	<.001	3	4
BRCA	GREM2 →	+0.807	+0.776	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050919 vs ERMN — GBM

Explore this scatter interactively →