Negative chemotaxis

Across TCGA cell cohorts, RNA activity of the Negative chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBED5, RPS23, and NRG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBED5 grouped by Negative chemotaxis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZBED5 →	+0.994	+0.796	.001	.001	3	4
URINARY_TRACT	RPS23 →	+0.923	+2.010	.001	<.001	3	4
LIVER	NRG2 →	+1.953	+0.356	.003	.007	2	4
BLOOD_Lymphoma	EEPD1 →	-5.276	-1.968	<.001	<.001	3	3
STOMACH	MYRF →	-1.938	-0.662	.008	.007	3	3
STOMACH	CLRN3 →	-4.103	-1.099	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBED5 by Negative chemotaxis activity — BREAST

Explore this box plot interactively →