Negative chemotaxis

Across TCGA cell cohorts, RNA activity of the Negative chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDLRAD3, MAP1S, and RAN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative chemotaxis activity versus LDLRAD3 in BLOOD_Lymphoma (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LDLRAD3 →	-1.425	-0.938	.004	<.001	3	4
LUNG_SCLC	MAP1S →	-0.694	-1.102	.002	<.001	3	4
URINARY_TRACT	RAN →	-0.560	-0.419	.001	.001	3	4
SKIN	UBE2H →	+0.933	+0.603	.006	.007	3	4
UPPER_AERODIGESTIVE_TRACT	POGLUT2 →	-0.615	-0.735	.002	.008	2	5
OVARY	SLC29A1 →	-1.334	-0.760	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050919 vs LDLRAD3 — BLOOD_Lymphoma

Explore this scatter interactively →