Sensory perception of umami taste

Across TCGA patient cohorts, RNA activity of the Sensory perception of umami taste pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITPR3, MAPK13, and DSP_S176, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of umami taste activity versus ITPR3 in GBM (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITPR3 →	+0.526	+0.814	<.001	<.001	3	8
HNSC	MAPK13 →	+0.313	+0.081	.007	.005	3	6
HNSC	DSP_S176 →	+0.738	+0.122	.002	<.001	3	6
CCRCC	SRPK1 →	+0.353	+0.143	<.001	.001	3	5
GBM	COLGALT1 →	+0.399	+0.612	<.001	<.001	3	5
CCRCC	HK2 →	+0.542	+0.120	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050917 vs ITPR3 — GBM

Explore this scatter interactively →