Sensory perception of umami taste

pathway activity — cross-omics
GO:0050917Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Sensory perception of umami taste pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIMREG, NOP14, and RNU11-6P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVPIMREG →-0.844-0.175.002.00234
BRCANOP14 →-0.405-0.624<.001<.00134
GBMRNU11-6P →-0.866-0.758.002.00134
GBMRPL23P5 →+0.116+0.612.001.00234
UCECRARRES2 →-0.997-0.326<.001<.00133
UCECGPRC5A →+1.038+0.259.006.00433
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration