Sensory perception of sweet taste

Across TCGA pan-cancer cohorts, RNA activity of the Sensory perception of sweet taste pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Sensory perception of sweet taste pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and BRCA, show the opposite pattern, with higher activity associated with better survival.

CESC, HNSC, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.823	0.919	.005	68	view →
HNSC	DFS	Median	IV	0.253	0.401	.003	32	view →
UCS	OS	Median	IV	0.817	0.302	.002	24	view →
THCA	OS	Median	All	0.872	0.986	.001	22	view →
BRCA	DFS	Tertile	II,III,IV	0.631	0.377	.012	21	view →
LGG	DFS	Median	All	0.580	0.285	<.001	18	view →
CHOL	OS	Median	All	0.168	1.000	<.001	15	view →
TGCT	DFS	Tertile	All	0.661	0.882	.009	12	view →
PCPG	DFS	Median	All	0.823	0.951	.014	10	view →
ESCA	DFS	Quartile	All	0.565	0.330	.009	9	view →
BLCA	DFS	Median	III,IV	0.219	0.400	.006	9	view →
SCLC	DFS	Median	III,IV	0.968	0.338	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0050916–CESC (OS)

Open the CESC breakdown →