Sensory perception of bitter taste

Across TCGA patient cohorts, RNA activity of the Sensory perception of bitter taste pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTRN, MCM2_S139, and AKAP12_S612, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of bitter taste activity versus UTRN in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UTRN →	+0.251	+0.045	.001	.007	3	5
BRCA	MCM2_S139 →	-0.431	-0.048	<.001	<.001	3	5
GBM	AKAP12_S612 →	+0.421	+0.039	.008	.002	3	5
HNSC	AKAP12 →	+0.440	+0.065	.002	.006	3	5
BRCA	RIF1_S2348 →	-1.034	-0.051	<.001	<.001	3	4
OV	CMAS →	+0.560	+0.038	.003	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050913 vs UTRN — LSCC

Explore this scatter interactively →