Sensory perception of bitter taste

Across TCGA patient cohorts, RNA activity of the Sensory perception of bitter taste pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGR, LRG1, and SLC44A4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of bitter taste activity versus PIGR in LSCC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PIGR →	+3.290	+0.557	<.001	<.001	3	9
BRCA	LRG1 →	+2.027	+0.260	<.001	<.001	3	6
BRCA	SLC44A4 →	+1.630	+0.235	<.001	<.001	3	6
GBM	VNN1 →	+0.567	+0.156	<.001	.002	3	6
LUAD	PLEKHG7 →	+0.573	+0.577	.003	.003	3	6
LSCC	TMC5 →	+1.561	+0.394	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050913 vs PIGR — LSCC

Explore this scatter interactively →