Detection of chemical stimulus involved in sensory perception of taste

Across TCGA patient cohorts, RNA activity of the Detection of chemical stimulus involved in sensory perception of taste pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGR, CTSS, and TMC5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of chemical stimulus involved in sensory perception of taste activity versus PIGR in UCEC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIGR →	+2.717	+0.274	<.001	<.001	3	8
GBM	CTSS →	+0.861	+0.180	<.001	<.001	3	6
LSCC	TMC5 →	+1.389	+0.647	<.001	.002	3	6
BRCA	LRG1 →	+1.581	+0.324	<.001	.003	3	6
PDAC	CARD16 →	+0.283	+0.158	.002	.005	2	7
LSCC	PSMB8-AS1 →	+0.557	+0.679	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050912 vs PIGR — UCEC

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