Detection of chemical stimulus involved in sensory perception of taste

Across TCGA cell cohorts, RNA activity of the Detection of chemical stimulus involved in sensory perception of taste pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CERK, DDX25, and DOK1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of chemical stimulus involved in sensory perception of taste activity versus CERK in LARGE_INTESTINE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CERK →	+1.891	+1.565	.004	.004	3	1
LARGE_INTESTINE	DDX25 →	+0.056	+1.944	.003	.004	3	1
LARGE_INTESTINE	DOK1 →	+1.180	+1.991	.001	.005	3	1
LARGE_INTESTINE	SLC19A2 →	-0.776	-1.565	<.001	.004	3	1
LARGE_INTESTINE	GLYATL2 →	+0.067	+1.926	<.001	<.001	3	1
LARGE_INTESTINE	ACE →	+2.474	+2.122	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050912 vs CERK — LARGE_INTESTINE

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