Detection of mechanical stimulus involved in sensory perception of sound

Across TCGA patient cohorts, RNA activity of the Detection of mechanical stimulus involved in sensory perception of sound pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYEF2_S17, HK2, and SEPSECS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of mechanical stimulus involved in sensory perception of sound activity versus MYEF2_S17 in PDAC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MYEF2_S17 →	+0.741	+0.045	<.001	<.001	3	5
BRCA	HK2 →	-0.355	-0.024	.004	.003	3	5
LSCC	SEPSECS →	+0.244	+0.051	<.001	.001	3	4
LSCC	SFN →	-0.545	-0.037	.001	<.001	3	4
LUAD	RGS10 →	-0.306	-0.055	<.001	<.001	3	4
PDAC	GKAP1 →	+0.662	+0.072	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050910 vs MYEF2_S17 — PDAC

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