Detection of mechanical stimulus involved in sensory perception of sound

Across TCGA patient cohorts, RNA activity of the Detection of mechanical stimulus involved in sensory perception of sound pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR1, DRAM1, and ARSB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of mechanical stimulus involved in sensory perception of sound activity versus TLR1 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TLR1 →	+0.770	+0.540	.003	.002	3	4
COAD	DRAM1 →	+0.426	+0.598	.004	.003	3	3
OV	ARSB →	+0.498	+0.522	.002	.002	3	3
OV	GALNT15 →	+0.748	+0.477	.008	.001	2	4
HNSC	KCNJ15 →	+0.798	+0.933	.006	.001	3	3
OV	TMEM71 →	+0.542	+0.560	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050910 vs TLR1 — OV

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