Detection of mechanical stimulus involved in sensory perception of sound

Across TCGA cell cohorts, RNA activity of the Detection of mechanical stimulus involved in sensory perception of sound pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRN3P2, AHRR, and CD96, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRN3P2 grouped by Detection of mechanical stimulus involved in sensory perception of sound-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RRN3P2 →	+0.153	+1.165	.004	<.001	3	5
URINARY_TRACT	AHRR →	-0.227	-1.401	<.001	.007	3	4
LUNG_NSCLC_LUSC	CD96 →	+0.208	+1.165	.001	.001	3	4
KIDNEY	CHFR →	+0.228	+1.451	.001	<.001	3	4
LUNG_NSCLC_LUAD	GRHPR →	+0.182	+0.903	<.001	<.001	3	4
SOFT_TISSUE	NEMP1 →	+0.227	+1.248	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRN3P2 by Detection of mechanical stimulus involved in sensory perception of sound activity — SOFT_TISSUE

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